Pharmacokinetics and biotransformation of beraprost sodium. VI. Metabolism and excretion of beraprost sodium in dog.
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منابع مشابه
Ameliorative Effect of Beraprost Sodium on Celecoxib Induced Cardiotoxicity in Rats
Selective COX-2 inhibitors are most widely used analgesic and anti-inflammatory drugs;however, its maximal use is highly associated with various serious abnormal cardiovascularevents. Beraprost sodium (BPS), prostacyclin analogue has been shown to vasodilatory,antiplatelates, anti-inflmmatory, and antioxidant activity. The objective of the present study wasto evaluate the effect of BPS on celec...
متن کاملAmeliorative Effect of Beraprost Sodium on Celecoxib Induced Cardiotoxicity in Rats
Selective COX-2 inhibitors are most widely used analgesic and anti-inflammatory drugs;however, its maximal use is highly associated with various serious abnormal cardiovascularevents. Beraprost sodium (BPS), prostacyclin analogue has been shown to vasodilatory,antiplatelates, anti-inflmmatory, and antioxidant activity. The objective of the present study wasto evaluate the effect of BPS on celec...
متن کاملEffects of beraprost sodium on renal function and inflammatory factors of rats with diabetic nephropathy.
Beraprost sodium (BPS) is a prostaglandin analogue. We investigated its effects on rats with diabetic nephropathy. There were 20 rats each in the normal control group (NC), the diabetic nephropathy group (DN), and the BPS treatment group. The rats in DN and BPS groups were given a high-fat diet combined with low-dose streptozotocin intraperitoneal injections. The rats in the BPS group were give...
متن کاملBeneficial Effect of Beraprost Sodium Plus Aspirin in the Treatment of Acute Ischemic Stroke
BACKGROUND To investigate the combination of beraprost sodium (BPS) and aspirin in the treatment of acute ischemic stroke (AIS). MATERIAL AND METHODS 308 patients with acute cerebral infarction were randomly divided into two groups: experimental group (n=154), treated with BPS (40 μg, tid) and aspirin (100 mg, qd); control group (n=154), treated with 100 mg of aspirin, qd). The antiplatelet the...
متن کاملProtective effect of beraprost sodium, a stable prostacyclin analogue, on cardiac allograft vasculopathy in rats.
Intimal thickening and luminal narrowing of the coronary arteries are insidious complications of cardiac allograft. However, the pathogenesis of cardiac allograft vasculopathy (CAV) remains to be clarified. In this study, the protective effect of a prostacyclin analogue (beraprost sodium; BPS) on CAV was evaluated after heterotopic cardiac transplantation in rat. All recipients were treated wit...
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ژورنال
عنوان ژورنال: Drug Metabolism and Pharmacokinetics
سال: 1989
ISSN: 0916-1139
DOI: 10.2133/dmpk.4.779